মঙ্গলবার, ২ এপ্রিল, ২০১৩

AstraZeneca suffers fresh drug patent setback in U.S.

LONDON (Reuters) - AstraZeneca has suffered a fresh patent setback with a U.S. court decision that a patent protecting its Pulmicort Repsules asthma treatment is invalid, clearing the way for a generic copy from Actavis.

The ruling comes as AstraZeneca is already facing a big fall in sales due to patent expiries on other medicines, prompting a $2.3 billion restructuring plan and further job losses announced by new CEO Pascal Soriot last month.

AstraZeneca said on Tuesday it strongly disagreed with the court's decision and was considering next steps, including lodging an appeal.

The District Court for the District of New Jersey ruled in favor of Actavis, which has developed a generic version that it now intends to launch immediately.

The verdict will not change AstraZeneca's revenue guidance for 2013, which is that the company anticipates a mid to high-single digit decline in sales.

But Britain's second-biggest drugmaker said additional generics entering the U.S. market would materially impact royalties received on sales of Teva's existing generic version of Pulmicort Repsules. Teva already has a generic on the market following an earlier deal with AstraZeneca.

Total branded and generic sales of Pulmicort Repsules were around $1.2 billion in the United States in the 12 months to January 2013, according to Actavis.

(Reporting by Ben Hirschler; Editing by Louise Heavens)

Source: http://news.yahoo.com/astrazeneca-suffers-fresh-drug-patent-setback-u-065000317--finance.html

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সোমবার, ১ এপ্রিল, ২০১৩

Primer On Small Cap Investing And Why Goldman's Research On It ...

confused. for goldman

Investors have been pretty happy lately because the US stock markets is up about 10 percent for the year through March. Since investors are happy, their overall level of investing fear is pretty low.

We know this because there is an index we use to gauge investor fear, and that index is down about 30 percent for the year through March. The fear gauge, the VIX, is down, indicating that investors aren?t very fearful right now.

According to Barron?s, Goldman Sachs believes that when we go through periods of low fear, like right now, small capitalization stocks tend to do well shortly after this decline in the fear gauge. Small cap stocks are ?small? companies,?measured by their stock price and number of stocks outstanding.?

Specifically, Goldman?s research shows that some small capitalization stocks outperform large capitalization stocks?by a median annualized 8.1 percent in quarters that follow especially rapid declines in the VIX index. Large cap stocks are like what you?d find in an?S&P index fund, that index consists of?large companies.

And then they go on to provide a fancy chart to support their claim that when the fear gauge is low, this provides a good tailwind for small cap stocks. Here?s their chart, forget about the fact that the chart is missing some key information, we?ll get to that in a second.

Here?s what you need to know:

This is the part that Barron?s (or Goldman) forgot to include: Small capitalization stocks generally lose more money when things are bad and make a lot more money when things are good.?They?re small companies, less robust, and so they?re more sensitive to the market environment.

And this is why Goldman left out 2001, 2007 and 2008, in their fancy chart. Years when the fear gauge (the VIX) spiked, and small capitalization stocks sucked wind. This is coincidentally the most important thing to understand with small capitalization stock fund investing.

So where are the years 2001, 2002, 2007, and 2008 in this chart?

They left those out because:

1) Fear (or the VIX) spiked those years.

2) And small capitalization stocks tanked.

If the fear gauge is low like it is now, that?s not a reason to buy small cap stocks.

You buy small capitalization stock funds if you believe:

1) They?re undervalued. PS no mention of this in the Barrons article?

and/or

2) You believe that the stock market is going increase. And, you?re willing to take the risk that if the market goes down, you?ll lose more than you would in large capitalization stocks.

Just because volatility is low doesn?t mean small caps are going to outperform large caps.?That?s the whole ?correlation does not equal causation? thing people talk about. If two things are somewhat correlated it doesn?t mean that one causes the other (in this case, the low fear gauge (VIX) does not cause small cap stocks to do well, even though the Goldman research wants you to believe that).

(Barron?s)

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Source: http://makinsensebabe.com/primer-on-small-cap-investing-and-why-goldmans-research-on-it-doesnt-make-sense/

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South Africa: Mandela in hospital on Easter

JOHANNESBURG (AP) ? Former South African President Nelson Mandela remained in a hospital on Easter Sunday while receiving treatment for a recurrence of pneumonia, the government said.

South African presidential spokesman Mac Maharaj said there are no updates on 94-year-old Mandela since an official statement Saturday on his condition. That statement reported the anti-apartheid leader was breathing without difficulty after having a procedure to clear fluid in his lung area.

Many South African congregations celebrating Easter included Mandela in their prayers.

"The whole world must come together and pray for him," Zacheus Phakathi, a security guard, said at an outdoor service on a hill overlooking Johannesburg.

In Pretoria, the capital, Henry Hyar, a restaurant waiter, standing by a hospital where Mandela is believed to be, said it was unfortunate that Mandela could not be with his family at home during Easter.

"I'm not happy about it," Hyar said. "We're praying for him to get better as soon as possible."

Mandela was admitted to a Pretoria hospital near midnight Wednesday. It was his third trip to a hospital since December, when he was treated for a lung infection and also had a procedure to remove gallstones. Earlier in March, he spent a night in a hospital for what officials said was a scheduled medical test.

Mandela became South Africa's first black president in 1994 after elections were held, bringing an end to the system of white racist rule known as apartheid. After his release from prison in 1990, Mandela was widely credited with averting even greater bloodshed by helping the country in the transition to democratic rule.

The Nobel Peace Prize laureate has been particularly vulnerable to respiratory problems since contracting tuberculosis during his 27-year imprisonment for fighting white racist rule in his country.

The elderly are especially vulnerable to pneumonia, which can be fatal. Its symptoms include fever, chills, a cough, chest pain and shortness of breath. Many germs cause pneumonia.

The office of South African President Jacob Zuma has said doctors were acting with extreme caution because of the Mandela's advanced age.

___

Associated Press television cameraman Bram Janssen contributed to this report from Pretoria, South Africa.

Source: http://news.yahoo.com/south-africa-mandela-hospital-easter-112931330.html

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Video: The state of religion in America (cbsnews)

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রবিবার, ৩১ মার্চ, ২০১৩

Afghans warned: The taxman is coming after you

By Katharine Houreld

KABUL (Reuters) - One of Afghanistan's most surprising success stories lies tucked away on a potholed street notorious for suicide bombings and lined with rusting construction equipment.

The work of the country's top tax collector is more inspiring than the view from his office in Kabul. Taxes and customs raised $1.64 billion last financial year, a 14-fold increase on 10 years ago. That means, now, the government can pay just over half of its recurrent costs such as salaries.

Thanks to tougher enforcement procedures, Afghanistan's tax to GDP ratio today stands above 11 percent - ahead of neighboring Pakistan's dismal 9 percent.

Increasing revenues is vital as donors begin reducing aid ahead of the 2014 drawdown of NATO troops, who have provided the backbone for security since U.S. forces invaded after the September 11 attacks on the United States.

By the end of this year the United States alone will have spent $100 billion on Afghan reconstruction. But future pledges are a fraction of that.

"We are largely dependent on international aid. We would like to be independent," said Abdurrahman Mujahid, the new head of the revenue department. "I would like a sustainable Afghanistan for all the children."

Despite rising revenues, the government will rely heavily on donors for years to come. Taxes, customs and mining revenue will only meet $2.5 billion out of a $7 billion budget this year.

Most of the revenue comes from large corporate taxpayers, who complain their payments have not improved power cuts, potholed roads or security.

Corporations pay a flat tax of 20 percent - the same rate for an individual earning over $2,000 a month.

But unlike developed countries where personal income tax generates a sizeable chunk of revenue, most Afghans scoff at the idea of giving the government some of their meager earnings.

The average annual income, in a country ranked one of the world's poorest, is just $470, according to the World Bank. Those making less than $100 a month don't have to pay tax.

"It's not a good government," said moneychanger Abdurrahman Arif, 28, as he held a wad of soiled notes and scanned for customers. "I don't pay tax. The rich people don't and the government should go to them before they come to me."

Afghanistan has a similar problem to neighboring Pakistan - the very wealthy don't pay their share, and weak institutions often have little way of forcing them.

Authorities admit that taxing the rich isn't easy in a country where the powerful often command militias. But Mujahid promises tax evaders will "be introduced to the law enforcement agencies".

SUBSTANTIAL ACHIEVEMENT

Much of Afghanistan's money is in an undocumented black economy. Corruption is endemic and the country produces 90 percent of the world's opium. Billions of dollars in cash leave the country every year in suitcases.

The security situation is discouraging. Taliban and other militias have made gains in many areas as foreign combat forces wind down their missions.

But some Afghans still manage to make money. Many businesses are fuelled by the aid dollars that have poured into the country over the last decade. Luxury supermarkets, travel agencies and stationery shops crowd the capital's streets.

A U.S. embassy official in Kabul commended Afghanistan's ability to raise tax revenues.

"It's a pretty substantial achievement," the official said, but noted the nation still faced a large funding gap, partly because of its huge security bill.

"It's going to continue being a problem until they can get revenues from the extractive industry, and that's going to take some time," the official said, referring to Afghanistan's rich but undeveloped mineral deposits.

Donors currently pay for just under half Afghanistan's operating costs - mostly government salaries - and more than three-quarters of all development projects like roads, dams and electricity equipment.

Rampant corruption means this money is often stolen, angering donors, fuelling anti-government rage and keeping aid from some of the world's neediest families.

Donors hope that if Afghans foot more of the bill for public services they may become less tolerant of graft from their leaders.

PUGNACIOUS PREDECESSOR

Mujahid, the new head of the revenue department, has large shoes to fill. His predecessor Ahmad Shah Zamanzai oversaw much of the department's growth and didn't shrink from confrontation.

When a vice-president refused to pay tax on income from renting out houses he owned, Zamanzai threatened to leak it to the press. Elections were approaching. The vice president paid up.

Under Zamanzai, the tax department jailed more than 20 tax evaders, froze bank accounts, slapped on travel bans and shuttered the premises of businesses that refused to pay.

In one showdown, he took on the glitzy wedding halls that have mushroomed up in the capital. When the 60 or so venues refused to pay their dues, he had police padlock a dozen of the biggest until the rest fell into line.

Zamanzai was appointed head of the state-run Pashtany Bank as part of a bureaucratic reshuffle this month. His first task, he said, would be to use skills honed in the tax department to extract overdue loan repayments from powerful Afghans.

But the tough tax enforcement has angered some businessmen.

Najib Ullah Latify's spotless factory, full of humming machinery and rows of workers in blue overalls and yellow hard hats, stands a few minutes drive from the tax office. High Standard Pipe employs 850 people and supplies pipes for projects providing clean water all over Afghanistan.

Latify said he'd expand but harassment from the tax man was hurting his business.

In recent years, he says, he's been repeatedly overcharged by the tax office and promised refunds have not been credited. Officials frequently offer to slash his tax bill in return for bribes, he added. When he refuses, he says, officials disrupt his imports and suspend his license.

"I don't know what to do, I have shouted everywhere that they are ruining my business," he said.

"I don't mind paying taxes. Even if 60 percent of it is spent on drinking and shopping and trips for (politicians') wives, maybe 40 percent will go to schools or hospitals. But they must tax me correctly."

The new tax chief, Mujahid, was not familiar with Vitaly's case, but promised to investigate. More than 10 tax collectors - whose basic salaries start at $180 a month - have been fired for corruption in the last two years.

"Corruption is a part of public life in Afghanistan," said Mujahid. "We have the aim to make this department corruption-free."

This year he's planning to finish computerizing tax records, usher through a law on Value Added Tax, and strengthen collection in the provinces - more than 90 percent of government taxes currently come from the capital.

"There's a lot of achievements, but for sure we have problems, and the biggest problem is corruption," he said.

(Editing by Jeremy Laurence)

Source: http://news.yahoo.com/afghans-warned-taxman-coming-075922090.html

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Razer begins shipping Edge units to those who pre-ordered this month

Razer begins shipping Edge units to those who preordered this month

Back when the Razer Edge pre-orders kicked off, on March 1st, the company wasn't quite clear as to when exactly the device would commence shipping to early adopters, only going as far as saying it would be later that very month. Well, the good news is today Razer took to its own Facebook page to announce that its new-era gaming PC is now on its way to folks who put in a pre-order "from the March batch." Meanwhile, Razer's hoping other gamers will also shell out the hefty amount of $999-plus for its novel piece of hardware, urging potential buyers on the social network to snag a unit (or two) before they go out of stock -- just don't expect to get a keyboard dock with your order, as the previously reported Q3 availability for this add-on remains intact. Above all, however, it's a great thing to see that what was once just a project, is now getting ready to arrive at consumers' doorsteps.

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Source: Razer (Facebook)

Source: http://www.engadget.com/2013/03/29/razer-edge-now-shipping/

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Man Tattoos Pitbull, Defends Actions as Dog Lover

Source: http://www.thehollywoodgossip.com/2013/03/man-tattoos-pitbull-defends-actions-as-dog-lover/

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